|
West Nile viral infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
The overall results suggest that OPN facilitates WNV neuroinvasion by recruiting WNV-infected PMNs into the brain.
|
28680095 |
2017 |
|
West Nile Fever
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our data suggests that OPN expression at early time points may provide protection against viral spread in the CNS by negatively controlling the type I IFN-sensitive, caspase 1-dependent inflammasome, while promoting an alternative caspase 8-associated pathway, to control the apoptosis of infected cells during WNV infection in the CNS.
|
28811681 |
2017 |
|
West Nile Fever
|
0.020 |
Biomarker
|
disease |
BEFREE |
Interestingly, WNV-infected OPN deficient (Opn <sup>-/-</sup>) mice exhibited a higher survival rate (70%) than wild type (WT) control mice (30%), suggesting OPN plays a deleterious role in WNV infection.
|
28680095 |
2017 |
|
Well Differentiated Hepatocellular Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transmembrane receptor CXCR7 increases the risk of extrahepatic metastasis of relatively well-differentiated hepatocellular carcinoma through upregulation of osteopontin.
|
23636305 |
2013 |
|
Von Hippel-Lindau Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with VHL syndrome had significantly higher plasma OPN levels than healthy volunteers.
|
12538452 |
2003 |
|
Vomiting
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Vitamin D-Resistant Rickets, X-Linked
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our findings of an excess of inhibitory OPN near osteocytes and their cell processes, and in dentin, spatially correlates with the defective mineralization observed at these sites in the skeleton and teeth of XLH patients.
|
27884786 |
2017 |
|
Vitamin D-Resistant Rickets, X-Linked
|
0.030 |
Biomarker
|
disease |
BEFREE |
These data suggest that both MEPE and OPN are involved in impaired tooth mineralization associated with XLH, possibly through different effects on the mineralization process.
|
25158186 |
2014 |
|
Vitamin D-Resistant Rickets, X-Linked
|
0.030 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry revealed altered OPN and DMP1 associated with an increased alkaline phosphatase staining in the XLH cultures.
|
28880715 |
2018 |
|
Visual seizure
|
0.200 |
Biomarker
|
disease |
RGD |
Osteopontin in kainic acid-induced microglial reactions in the rat brain.
|
12132583 |
2002 |
|
Virus Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
We discovered species-specific colocalization of osteopontin with the follicular dendritic cell (FDC) network in lymphatic tissues in HIV-1 and simian immunodeficiency virus infections, and we found that changes in FDC-associated osteopontin covary with changes in lymphoid follicles during acute and late stages of infection and in response to treatment.
|
16136472 |
2005 |
|
Virus Diseases
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Herein, we report on the role of osteopontin (OPN) in regulation of RSV infection in human epithelial cells and how interleukin-1 beta (IL-1β), a cytokine secreted soon after RSV infection, when persistently expressed can induce OPN expression leading to increased viral infection.
|
29677209 |
2018 |
|
Virus Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
Based on our findings of enhanced osteopontin (OPN) expression in inflamed human hearts, we further investigated in the murine model of acute and chronic coxsackievirus (CV)B3-myocarditis the role of OPN regarding its involvement in resolution of cardiac virus infection and fibrosis.
|
19246678 |
2009 |
|
Vesico-Ureteral Reflux
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Renal scarring and osteopontin gene C/T polymorphism in children with primary vesicoureteral reflux.
|
22080623 |
2012 |
|
Ventricular hypertrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study provides the first evidence that cardiomyocytes are a prominent source of OP in vivo and suggests that induction of OP expression is strongly associated with ventricular hypertrophy.
|
9386176 |
1997 |
|
Vascular lesions
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fibrogenesis is associated with re-expression of embryonic preserved tissue developmental mediators: osteopontin (OPN), regulated by sex-determining region Y‑box 9 (Sox9), and homeobox A9 (HoxA9) play important roles in pathologic tissue remodeling and are upregulated in atherosclerotic vascular lesions; dickkopf-1 (DKK1) inhibits pro-fibrotic and atherogenic Wnt signaling.
|
28812103 |
2017 |
|
Vascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
OPN could be considered a marker of vasculopathy and subclinical atherosclerosis in pediatric T1DM.
|
29687557 |
2018 |
|
Vascular Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
With the recent finding that humans express multiple OPN isoforms as the result of alternative splicing and that these isoforms have distinct biologic functions, future studies are required to determine what OPN isoform(s) are expressed in the setting of vascular disease and what role each of these isoforms plays in vascular disease progression.
|
30727754 |
2019 |
|
Vascular calcification
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
A variety of extracellular matrix molecules such as collagen type 1, bone sialoprotein, and osteopontin are known to regulate the biomineralization of bone and ectopic vascular calcification.
|
15472131 |
2004 |
|
Vascular calcification
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is involved in mineral metabolism and the inflammatory response while diabetes mellitus is associated with severe and extensive vascular calcification.
|
27743892 |
2016 |
|
Vascular calcification
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Evidence from the literature suggests that OPN may fit within the Goldilocks paradigm with respect to cardiovascular disease, where acute increases are protective, attenuate vascular calcification, and promote postischemic neovascularization.
|
30727754 |
2019 |
|
Vascular calcification
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, OPN may also possess potentially protective vascular effects, such as attenuation of vascular calcification.
|
25128758 |
2014 |
|
Vascular calcification
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
The relationship of osteopontin (OPN) - which is known as a vascular calcification inhibitor - and fibroblast growth factor-23 (FGF-23) - which its related to vascular calcification, as recently shown - to valvular calcification is unknown.
|
30369401 |
2019 |
|
Vascular calcification
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these demonstrated that OPN exerts an important role in the monocytes/macrophage phenotypic differentiation from hypertensive patients with VC, which includes reducing inflammatory factor expression and attenuating osteoclast formation.
|
28091516 |
2017 |
|
Vascular calcification
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Osteoprotegerin (OPG) and osteopontin (OPN) are involved in both VC and CKD.
|
29407881 |
2018 |